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Adenine

CAT: 0804-HY-B0152-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0152-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Adenine (6-Aminopurine), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine acts as a chemical component of DNA and RNA. Adenine also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis[1][2][3].
CAS Number
73-24-5
UNSPSC
12352005
Hazard Statement
H301, H401
Target
DNA/RNA Synthesis; Endogenous Metabolite
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Adenine.html
Purity
99.99
Solubility
DMSO : ≥ 10 mg/mL|H2O : 2 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
NC1=C2N=CNC2=NC=N1
Molecular Formula
C5H5N5
Molecular Weight
135.13
Precautions
H301, H401
References & Citations
[1]ORO J, et al. Synthesis of purines under possible primitive earth conditions. I. Adenine from hydrogen cyanide. Arch Biochem Biophys. 1961 Aug;94:217-27.|[2]Griffiths AJF, et al. An Introduction to Genetic Analysis. 7th edition. New York: W. H. Freeman; 2000. Structure of DNA.|[3]Reader V. The assay of vitamin B (4) . Biochem J. 1930;24 (6) :1827-31.|[4]Yung-Jen Tsai, et al. Pharmacokinetics of Adenosine and Cordycepin, a Bioactive Constituent of Cordyceps sinensis in Rat. J Agric Food Chem 2010 Apr 28;58 (8) :4638-43.|[5]Fatma F Mohamed, et al. Dentoalveolar Alterations in an Adenine‐Induced Chronic Kidney Disease Mouse Model. J Bone Miner Res. 2023 Aug;38 (8) :1192-1207.|[6]Chien-Ning Hsu, et al. Sodium Thiosulfate Improves Hypertension in Rats with Adenine-Induced Chronic Kidney Disease. Antioxidants (Basel) . 2022 Jan 11;11 (1) :147.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
Launched
Isoform
Human Endogenous Metabolite; Microbial Metabolite

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