Dactolisib hydrochloride

• Target:

  PI3K|||mTOR|||Autophagy

• Related Pathways:

  Autophagy|||PI3K/Akt/mTOR signaling

• Bioactivity:

  Dactolisib (BEZ235) hydrochloride is an orally active dual inhibitor of pan-class I PI3K and mTOR, targeting p110?/?/?/? and mTOR, with IC50 values of 4 nM, 5 nM, 7 nM, 75 nM, and 20.7 nM, respectively. It inhibits both mTORC1 and mTORC2.

• Smiles:

  Cl.N#CC(C1=CC=C(C=C1)N2C(=O)N(C=3C=NC4=CC=C(C=C4C32)C=5C=NC6=CC=CC=C6C5)C)(C)C

• Molecular Formula:

  C30H24ClN5O

• Molecular Weight:

  506

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2319647-83-9