Dactolisib

CAT: 0931-T2235-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T2235-01Size:25 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

915019-65-7

Target

Autophagy, mTOR, ATM/ATR, PI3K

Related Pathways

Autophagy, DNA Damage/DNA Repair, PI3K/Akt/mTOR signaling

Purity

0.9985

Bioactivity

Dactolisib (BEZ235) is an orally bioavailable inhibitor of PI3K and mTOR, with IC50 values of 4 nM for p110α, 5 nM for p110γ, 7 nM for p110δ, 75 nM for p110β, and 20.7 nM for mTOR.

Smiles

O=C1N(C=2C=3C(N=CC2N1C)=CC=C(C3)C4=CC5=C(N=C4)C=CC=C5)C6=CC=C(C(C#N)(C)C)C=C6

Molecular Formula

C30H23N5O

Molecular Weight

469.54

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

Dactolisib

Dactolisib is an imidazoquinoline that is 3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinoline substituted at position 1 by a 4-(1-cyanoisopropyl)phenyl group and at position 8 by a quinolin-3-yl group. A dual PI3K/mTOR inhibitor used in cancer treatment. It has a role as an antineoplastic agent, an EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor and a mTOR inhibitor. It is a nitrile, a member of quinolines, a ring assembly, an imidazoquinoline and a member of ureas.

CAS Number	915019-65-7
PubChem CID	11977753
IUPAC Name	2-methyl-2-[4-(3-methyl-2-oxo-8-quinolin-3-ylimidazo[4,5-c]quinolin-1-yl)phenyl]propanenitrile
Molecular Formula	C30H23N5O
Molecular Weight	469.5
XLogP	5.2
Topological Polar Surface Area	73.1
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	3
Heavy Atom Count	36
Formal Charge	0
Complexity	872

SMILES

CC(C)(C#N)C1=CC=C(C=C1)N2C3=C4C=C(C=CC4=NC=C3N(C2=O)C)C5=CC6=CC=CC=C6N=C5

InChI

InChI=1S/C30H23N5O/c1-30(2,18-31)22-9-11-23(12-10-22)35-28-24-15-19(21-14-20-6-4-5-7-25(20)32-16-21)8-13-26(24)33-17-27(28)34(3)29(35)36/h4-17H,1-3H3

InChIKey

JOGKUKXHTYWRGZ-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 915019-65-7

CID: 11977753

Formula: C30H23N5O

MW: 469.5

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	469.5
XLogP3	5.2
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	3
Exact Mass	469.19026037
Monoisotopic Mass	469.19026037
Topological Polar Surface Area	73.1 Å²
Heavy Atom Count	36
Formal Charge	0
Complexity	872
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
HY-50673-01	Dactolisib
HY-50673A-01	Dactolisib (hydrochloride)
GTR19203942-01	Dactolisib Tosylate
C16055-200mg	Dactolisib (BEZ235)
GTR19240948-01	Dactolisib hydrochloride
HY-15174-01	Dactolisib (Tosylate)

Dactolisib

Chemical Information

Alternative Products

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