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Dactolisib (BEZ235)

CAT: 1568-C16055-200mgSize: 200 mgDry Ice: YesHazardous: No
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CAT#:1568-C16055-200mgSize:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
915019-65-7
Synonyms
NVP-BEZ235
Target
ATM/ATR
Applications
PI3K/Akt/mTOR
Smiles
CC (C) (C#N) C1=CC=C (C=C1) N2C3=C4C=C (C=CC4=NC=C3N (C2=O) C) C5=CC6=CC=CC=C6N=C5
Molecular Formula
C30H23N5O
Additionnal Information
Dactolisib (BEZ235, NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR (p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM in cell-free assays, respectively. Inhibits ATR with IC50 of 21 nM in 3T3TopBP1-ER cell. Dactolisib induces autophagy and suppresses HIV-1 replication. Phase 2.
Storage Conditions
2 years -80 in solvent

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