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CB2 receptor agonist 8

CAT: 0931-T203567-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T203567-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Caspase, Cannabinoid Receptor
Related Pathways
Proteases/Proteasome, GPCR/G Protein, Apoptosis
Bioactivity
CB2 receptor agonist 8 (Compound 17) is an agonist of the cannabinoid receptor 2 (CB2 receptor) . It shows cytotoxicity in U87, RPMI 8226, HL-60, and L929 cells with IC50 values of 91.03, 16.29, 23.51, and 564.6 μM, respectively. CB2 receptor agonist 8 activates caspase 3/7, increases the expression of pro-apoptotic genes BAX, BAD, BIM, and the tumor suppressor gene p53, and induces apoptosis in U87 cells. Additionally, it inhibits the migration of U87 cells.
Molecular Formula
C23H26FN3O2
Molecular Weight
395.47
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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