DBPR116

CAT: 0931-T203506-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T203506-01Size:10 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2131200-75-2

Target

Opioid Receptor

Related Pathways

Neuroscience, GPCR/G Protein, Endocrinology/Hormones

Bioactivity

DBPR116 is a prodrug of BPRMU191 that can penetrate the blood-brain barrier. It significantly enhances the delivery efficiency of drugs targeting the central nervous system. When combined with the antagonist Naltrexone, DBPR116 demonstrates superior safety and analgesic effects compared to morphine in various in vivo pharmacological studies, including thermal pain models, cancer pain models, constipation, sedation, psychological dependence, heart rate, and respiratory frequency. As a strategy for peripheral administration, DBPR116 effectively alleviates pain while reducing adverse effects, showing promise as a safer opioid analgesic.

Smiles

O=C(OCC)C1=CC=C(C(=C1)C)N2C(=O)CSC2C3=CC=C(F)C=C3

Molecular Formula

C19H18FNO3S

Molecular Weight

359.42

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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HY-159924	DBPR116

DBPR116

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