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DBPR112

CAT: 0931-T10965-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T10965-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1226549-49-0
Target
EGFR
Related Pathways
Angiogenesis, Tyrosine Kinase/Adaptors, JAK/STAT signaling
Purity
0.9925
Bioactivity
DBPR112 is an orally active furanopyrimidine-based EGFR inhibitor with IC50s of 15 nM for EGFRWT and 48 nM for EGFRL858R/T790M, capable of occupying the ATP-binding site and demonstrating significant antitumor efficacy.
Smiles
CN(C)C\C=C\C(=O)Nc1cccc(c1)-c1c(oc2ncnc(N[C@H](CO)c3ccccc3)c12)-c1ccccc1
Molecular Formula
C32H31N5O3
Molecular Weight
533.62
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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