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(R) -SR-C-107

CAT: 0931-T203270-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T203270-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Epigenetic Reader Domain
Related Pathways
Chromatin/Epigenetic
Bioactivity
(R) -SR-C-107 is an orally active inhibitor developed based on ENL (containing YEAST domain protein), designed to target acute myeloid leukemia (AML) . The inhibitor has an IC50 of 40 nM and a KD of 144 nM for ENL. In a xenograft mouse model of AML, (R) -SR-C-107 demonstrated in vivo efficacy, achieving a tumor regression rate of 45% at a dosage of 200 mg/kg (PO; QD) .
Molecular Formula
C21H23N7O
Molecular Weight
389.45
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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