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PROTAC KSP-IN-1

CAT: 0931-T203186-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T203186-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Kinesin, PROTACs, Apoptosis
Related Pathways
Cytoskeletal Signaling, PROTAC, Apoptosis
Bioactivity
PROTACKSP-IN-1 (Compound 21) is a spindle protein (KSP) degrader as a PROTAC, effectively degrading KSP in HCT-116 cells with a DC50 value of 114.8 nM. It inhibits the proliferation of HCT-116 with an IC50 of 10 nM, causes G2/M phase cell cycle arrest, and induces apoptosis in HCT-116. Additionally, PROTACKSP-IN-1 demonstrates antitumor activity in mouse models.
Molecular Formula
C48H51N5O8S
Molecular Weight
858.01
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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