Clofarabine-5'-diphosphate

CAT: 0931-T203181-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T203181-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

167620-89-5

Target

DNA/RNA Synthesis

Related Pathways

Cell Cycle/Checkpoint, DNA Damage/DNA Repair

Bioactivity

Clofarabine-5'-diphosphate (Clofarabine-DP) is a metabolite resulting from the phosphorylation of Clofarabine by deoxycytidine kinase (dCK) . It can undergo further phosphorylation to become Clofarabine-5'-triphosphate, exhibiting cytotoxicity in cancer cells by inhibiting DNA synthesis and repair.

Smiles

F[C@@H]1[C@H](N2C=3C(N=C2)=C(N)N=C(Cl)N3)O[C@H](COP(OP(=O)(O)O)(=O)O)[C@H]1O

Molecular Formula

C10H13ClFN5O9P2

Molecular Weight

463.64

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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Clofarabine-5'-diphosphate

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