Clofarabine-5'-diphosphate (trisodium)

Clofarabine-5'-diphosphate (trisodium)

• UNSPSC Description: Clofarabine-5'-diphosphate trisodium (Clofarabine-DP trisodium) is the trisodium salt form of Clofarabine-5'-diphosphate (HY-164839). Clofarabine-5'-diphosphate trisodium is the metabolite of Clofarabine (HY-A0005) by deoxycytidine kinase (dCK) phosphorylation. Clofarabine-5'-diphosphate trisodium can be further phorphorylated into Clofarabine-5'-triphosphate, and exhibits cytotoxicity in cancer cells through inhibition of DNA synthesis and DNA repair[1].
• Target Antigen: DNA/RNA Synthesis
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/clofarabine-5-diphosphate-trisodium.html
• Smiles: NC1=NC(Cl)=NC2=C1N=CN2[C@H]3[C@@H](F)[C@H](O)[C@@H](COP(OP(O[Na])(O[Na])=O)(O[Na])=O)O3
• Molecular Weight: 529.58
• References & Citations: [1]Nagai S, et al., Deoxycytidine kinase modulates the impact of the ABC transporter ABCG2 on clofarabine cytotoxicity. Cancer Res. 2011 Mar 1;71(5):1781-91.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported