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TG-100435

CAT: 0931-T202894-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-T202894-01Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
867330-68-5
Target
Ephrin Receptor|||Bcr-Abl|||Src
Related Pathways
Cytoskeletal Signaling|||Angiogenesis|||Tyrosine Kinase/Adaptors
Bioactivity
TG-100435 is a novel multi-target oral protein tyrosine kinase inhibitor. The metabolic flux of TG100435 is entirely inhibited by methimazole and ketoconazole. In human liver microsomes or recombinant P450, the formation of TG100435 increases with the activity of cytochrome P450 reductase, suggesting that cytochrome P450 reductase may be involved.
Smiles
ClC=1C=CC=C(Cl)C1C2=CC=3N=NC(=NC3C(=C2)C)NC4=CC=C(OCCN5CCCC5)C=C4
Molecular Formula
C26H25Cl2N5O
Molecular Weight
494.42
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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