Emavusertib Phosphate

• Target:

  MyD88|||Apoptosis|||FLT|||IRAK|||NF-?B

• Related Pathways:

  Apoptosis|||Tyrosine Kinase/Adaptors|||NF-?B|||Angiogenesis|||Immunology/Inflammation

• Bioactivity:

  Emavusertib Phosphate (also known as CA-4948) is a potent inhibitor of IRAK4 and FLT3, exhibiting antitumor activity. In ABC DLBCL and AML cell lines, it demonstrates significant cellular efficacy. Furthermore, CA-4948 shows moderate to high selectivity across a panel of 329 kinases and possesses favorable ADME and PK profiles, including good oral bioavailability in mice, rats, and dogs. It achieves over 90% tumor growth inhibition in relevant tumor models and correlates excellently with in vivo PD modulation.

• Smiles:

  P (=O) (O) (O) O.N (C (=O) C=1N=C (OC1) C=2C=C (C) N=CC2) C3=C (N=C4C (=C3) OC (=N4) N5CCOCC5) N6CC[C@@H] (O) C6

• Molecular Formula:

  C24H28N7O9P

• Molecular Weight:

  589.49

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2376399-38-9