Foretinib phosphate

CAT: 0931-MF-0145433-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0145433-01Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1226999-07-0
Target
C-Met/HGFR|||VEGFR|||Others
Related Pathways
Tyrosine Kinase/Adaptors|||Angiogenesis|||Others
Bioactivity
Foretinib phosphate is an orally bioavailable small molecule with potential antineoplastic activity. MET/VEGFR2 inhibitor GSK1363089 binds to and selectively inhibits hepatocyte growth factor (HGF) receptor c-MET and vascular endothelial growth factor receptor 2 (VEGFR2), which may result in the inhibition of tumor angiogenesis, tumor cell proliferation and metastasis. The proto-oncogene c-MET has been found to be over-expressed in a variety of cancers.
Smiles
OP(O)(O)=O.OP(O)(O)=O.COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1
Molecular Formula
C34H40F2N4O14P2
Molecular Weight
828.65
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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CatalogName
MBS5813726Foretinib phosphate
HY-10338AForetinib (phosphate)
S1111-1gForetinib
A2974-10Foretinib (GSK1363089)
HY-10338R-01Foretinib (Standard)

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