Foretinib phosphate

• Target :

  C-Met/HGFR|||VEGFR|||Others

• Related Pathways :

  Tyrosine Kinase/Adaptors|||Angiogenesis|||Others

• Bioactivity :

  Foretinib phosphate is an orally bioavailable small molecule with potential antineoplastic activity. MET/VEGFR2 inhibitor GSK1363089 binds to and selectively inhibits hepatocyte growth factor (HGF) receptor c-MET and vascular endothelial growth factor receptor 2 (VEGFR2), which may result in the inhibition of tumor angiogenesis, tumor cell proliferation and metastasis. The proto-oncogene c-MET has been found to be over-expressed in a variety of cancers.

• Smiles :

  OP(O)(O)=O.OP(O)(O)=O.COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1

• Molecular Formula :

  C34H40F2N4O14P2

• Molecular Weight :

  828.65

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1226999-07-0