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Emavusertib Tosylate

CAT: 0931-T202760-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T202760-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2376399-41-4
Target
MyD88, NF-κB, IRAK, Apoptosis, FLT
Related Pathways
Tyrosine Kinase/Adaptors, Apoptosis, Angiogenesis, Immunology/Inflammation, NF-κB
Bioactivity
Emavusertib Tosylate (also known as CA-4948) is a potent inhibitor of IRAK4/FLT3 with demonstrated antitumor activity. In cell lines such as ABC DLBCL and AML, CA-4948 exhibits strong cellular efficacy. Among 329 evaluated kinases, it shows medium to high selectivity. The compound has excellent oral bioavailability and favorable pharmacokinetic properties in ADME and PK profiles. In preclinical models involving mice, rats, and dogs, CA-4948 demonstrated good oral bioavailability and displayed over 90% tumor growth inhibition in relevant tumor models, correlating well with in vivo pharmacodynamic regulation.
Smiles
S(=O)(=O)(O)C1=CC=C(C)C=C1.N(C(=O)C=1N=C(OC1)C=2C=C(C)N=CC2)C3=C(N=C4C(=C3)OC(=N4)N5CCOCC5)N6CC[C@@H](O)C6
Molecular Formula
C31H33N7O8S
Molecular Weight
663.7
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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