MS-8709

• Bioactivity :

  MS-8709 is a G9a/GLP PROTAC Degrader (DC50 (G9a) = 274 nM; DC50 (GLP) = 260 nM) that induces G9a/GLP degradation in a concentration-, time-, and ubiquitin-proteasome system (UPS) -dependent manner. It shows higher selectivity for G9a/GLP over other methyltransferases, without affecting G9a/GLP mRNA expression. In addition, MS-8709 demonstrates superior inhibition of prostate cancer, leukemia, and lung cancer cell growth compared to its parent compound, the G9a/GLP inhibitor UNC0642, and possesses favorable murine pharmacokinetic properties for in vivo efficacy studies.

• Smiles :

  N(C=1C2=C(N=C(N1)N3CCC(F)(F)CC3)C=C(OCCCN4CCCC4)C(OC)=C2)C5CCN(CCCC(NCCCCCCCCCCCC(N[C@H](C(=O)N6[C@H](C(NCC7=CC=C(C=C7)C8=C(C)N=CS8)=O)C[C@@H](O)C6)[C@](C)(C)C)=O)=O)CC5

• Molecular Formula :

  C64H95F2N11O7S

• Molecular Weight :

  1200.57

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  3060730-06-2