MS 154N

• Target:

  Others|||PROTACs|||EGFR

• Related Pathways:

  PROTAC|||JAK/STAT signaling|||Tyrosine Kinase/Adaptors|||Others|||Angiogenesis

• Bioactivity:

  MS 154N is a negative control for MS 154. The compound exhibits high binding-affinity for WT and L858R-mutant EGFR (Kdvalues are 3 and 4.3 nM, respectively), but does not significantly induce degradation of EGFR mutants.

• Smiles:

  O=C1C=2C(C(=O)N1C3C(=O)N(C)C(=O)CC3)=CC=CC2OCCCCCCCCNC(CCN4CCN(CCCOC5=CC6=C(C=C5OC)N=CN=C6NC7=CC(Cl)=C(F)C=C7)CC4)=O

• Molecular Formula:

  C47H56ClFN8O8

• Molecular Weight:

  915.45

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2675490-97-6