MS-073

• Target :

  Others|||P-gp

• Related Pathways :

  Others|||Membrane transporter/Ion channel|||Neuroscience

• Bioactivity :

  MS-073 (CP-162398) is a P-glycoprotein inhibitor (P-gp) . The in vitro resistance to vincristine (VCR) was almost completely reversed in VCR-resistant P388 cells, and the resistance of VCR, adriamycin (ADM), etoposide, and actinomycin D in ADM-resistant human myeloid leukemia K562 (K562/ADM) cells in vitro was also reversed. MS-073 reverses MDR by competitively inhibiting the binding of drugs to P-glycoprotein.

• Smiles :

  C(C(COC=1C2=C(C=CC1)N=CC=C2)O)N3CCN(C4C=5C(CCC=6C4=CC=CC6)=CC=CC5)CC3

• Molecular Formula :

  C31H33N3O2

• Molecular Weight :

  479.61

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  129716-45-6