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MS-073

CAT: 0931-T33510-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T33510-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
129716-45-6
Target
Others, P-gp
Related Pathways
Others, Membrane transporter/Ion channel, Neuroscience
Bioactivity
MS-073 (CP-162398) is a P-glycoprotein inhibitor (P-gp) . The in vitro resistance to vincristine (VCR) was almost completely reversed in VCR-resistant P388 cells, and the resistance of VCR, adriamycin (ADM), etoposide, and actinomycin D in ADM-resistant human myeloid leukemia K562 (K562/ADM) cells in vitro was also reversed. MS-073 reverses MDR by competitively inhibiting the binding of drugs to P-glycoprotein.
Smiles
C(C(COC=1C2=C(C=CC1)N=CC=C2)O)N3CCN(C4C=5C(CCC=6C4=CC=CC6)=CC=CC5)CC3
Molecular Formula
C31H33N3O2
Molecular Weight
479.61
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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