BD-Oligo

CAT: 0931-T202001-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T202001-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

1357578-02-9

Bioactivity

BD-Oligo is a promising fluorescent sensor designed for detecting Aβ oligomers. It effectively monitors the dynamics of these oligomers during fibril formation in vitro and shows potential for in vivo staining in Alzheimer's disease (AD) mouse models. The sensing mechanism is facilitated through π-π stacking interactions and hydrogen bonding between BD-Oligo and the exposed hydrophobic regions of Aβ oligomers, as confirmed by computational techniques. Furthermore, BD-Oligo can cross the blood-brain barrier (BBB) to detect oligomers in the brains of AD transgenic mice without causing toxicity.

Smiles

C(=C/C1=C(O)C(OCC)=CC=C1)\C2=[N]3C(=CC=4[N-]([B+3]3([F-])[F-])C(CCC(OCC(Cl)(Cl)Cl)=O)=CC4)C(C)=C2

Molecular Formula

C25H24BCl3F2N2O4

Molecular Weight

571.64

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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