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BD-Oligo

CAT: 0931-T202001-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-T202001-01Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1357578-02-9
Bioactivity
BD-Oligo is a promising fluorescent sensor designed for detecting A? oligomers. It effectively monitors the dynamics of these oligomers during fibril formation in vitro and shows potential for in vivo staining in Alzheimer's disease (AD) mouse models. The sensing mechanism is facilitated through ?-? stacking interactions and hydrogen bonding between BD-Oligo and the exposed hydrophobic regions of A? oligomers, as confirmed by computational techniques. Furthermore, BD-Oligo can cross the blood-brain barrier (BBB) to detect oligomers in the brains of AD transgenic mice without causing toxicity.
Smiles
C(=C/C1=C(O)C(OCC)=CC=C1)\C2=[N]3C(=CC=4[N-]([B+3]3([F-])[F-])C(CCC(OCC(Cl)(Cl)Cl)=O)=CC4)C(C)=C2
Molecular Formula
C25H24BCl3F2N2O4
Molecular Weight
571.64
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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