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Tesevatinib tosylate

CAT: 0931-T201865-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T201865-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1000599-06-3
Target
Src, EGFR, VEGFR
Related Pathways
Angiogenesis, JAK/STAT signaling, Tyrosine Kinase/Adaptors
Bioactivity
Tesevatinib tosylate (XL-647 tosylate) is an orally administered epidermal growth factor receptor (EGFR) inhibitor that can cross the blood-brain barrier. It significantly reduces cell viability with IC50 values of 11 nM and 102 nM in GBM12 and GBM6, respectively. Additionally, Tesevatinib tosylate inhibits HER2 (IC50=16.1 nM), VEGFR2 (IC50=1.5 nM), and Src (IC50=10.3 nM), demonstrating antitumor activity by inhibiting tumor proliferation.
Smiles
S(=O)(=O)(O)C1=CC=C(C)C=C1.N(C=1C2=C(C=C(OC[C@@H]3C[C@]4([C@@](C3)(CN(C)C4)[H])[H])C(OC)=C2)N=CN1)C5=C(F)C(Cl)=C(Cl)C=C5
Molecular Formula
C31H33Cl2FN4O5S
Molecular Weight
663.59
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

1000599-06-3

PubChem
cas1000599-06-3
PubChem LinkClick here

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