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Tesevatinib (Standard)

CAT: 0804-HY-13314RSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-13314RSize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Tesevatinib (Standard) is the analytical standard of Tesevatinib. This product is intended for research and analytical applications. Tesevatinib (XL-647) is an orally available, blood-brain barrier-penetrant inhibitor of the epidermal growth factor receptor (EGFR) . Tesevatinib significantly reduces cellular viability, with IC50 values of 11 nM and 102 nM in GBM12 and GBM6, respectively. Tesevatinib also inhibits HER2 (IC50=16.1 nM), VEGFR2 (IC50=1.5 nM), and Src (IC50=10.3 nM) . Tesevatinib can inhibit tumor proliferation and exhibits antitumor activity[1][2].
CAS Number
781613-23-8
UNSPSC
12352100
Target
EGFR; Reference Standards; Src; VEGFR
Related Pathways
JAK/STAT Signaling; Others; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
[H][C@@]12[C@@](C[C@@H](COC3=CC4=C(C(NC5=C(F)C(Cl)=C(Cl)C=C5)=NC=N4)C=C3OC)C2)([H])CN(C)C1
Molecular Formula
C24H25Cl2FN4O2
Molecular Weight
491.39
References & Citations
[1]Sani H Kizilbash, et al. In Vivo Efficacy of Tesevatinib in EGFR-Amplified Patient-Derived Xenograft Glioblastoma Models May Be Limited by Tissue Binding and Compensatory Signaling. Mol Cancer Ther. 2021 Jun;20 (6) :1009-1018.|[2]Steven B Gendreau, et al. Inhibition of the T790M gatekeeper mutant of the epidermal growth factor receptor by EXEL-7647. Clin Cancer Res. 2007 Jun 15;13 (12) :3713-23.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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