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HDACs/EZH2-IN-1

CAT: 0931-T201795-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T201795-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Target
Endogenous Metabolite, Histone Methyltransferase, HDAC
Related Pathways
Metabolism, Chromatin/Epigenetic, DNA Damage/DNA Repair
Bioactivity
HDACs/EZH2-IN-1 (Compound 22a) is a dual inhibitor of HDACs and EZH2, exhibiting potent inhibitory activity, with EZH2 Y641N being suppressed by 98% at 50 nM. It selectively targets HDAC1 and HDAC6, with IC50 values of 0.23 μM and 0.07 μM, respectively. HDACs/EZH2-IN-1 effectively inhibits the proliferation of diffuse large B-cell lymphoma cells harboring EZH2 mutations and various acute myeloid leukemia cells. Additionally, this compound has the capability to induce cellular differentiation and apoptosis (Apoptosis) .
Molecular Formula
C29H36BrN7O4
Molecular Weight
626.54
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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