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HDAC/HSP90-IN-4

CAT: 0931-T64261-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T64261-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Target
Others, HSP, HDAC
Related Pathways
Cytoskeletal Signaling, Metabolism, DNA Damage/DNA Repair, Others, Chromatin/Epigenetic
Bioactivity
HDAC/HSP90-IN-4 significantly inhibited HDAC and HSP90 activity, with compound 20 (HDACIC50= 194 nM; HSP90αIC50= 153 nM) and compound 26 ((HDACIC50= 360 nM; HSP90αIC50= 77 nM) having the strongest HDAC and HSP90α inhibition. effect. Both compounds induced HSP90 expression and down-regulated HSP90 client proteins, which play an important role in the regulation of cancer cell survival and invasion.
Molecular Formula
C20H23N3O6
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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