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PROTAC MPS1 degrader 1

CAT: 0931-T201080-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T201080-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Target
PROTACs, Kinesin, Aurora Kinase
Related Pathways
Chromatin/Epigenetic, Cytoskeletal Signaling, Cell Cycle/Checkpoint, PROTAC
Bioactivity
PROTAC MPS1 degrader 1 (Compound 19) acts as a potent degrader of Monopolar spindle 1 (Mps1, TTK), AURKA, and AURKB, with DC50 values of 17.7, 108.7, and 570.3 nM respectively. It is utilized in the study of acute myeloid leukemia. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligase)
Smiles
O(C)C=1C=C2C(=CC1OC)CCN(CCC3=CC=C(/N=N/C4=C(NC(=O)C5=C(OC)C=CC=C5)C=CC=C4)C=C3)C2
Molecular Formula
C41H46N12O7
Molecular Weight
818.88
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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