BCR-ABL-IN-9

• Target:

  Bcr-Abl

• Related Pathways:

  Tyrosine Kinase/Adaptors|||Cytoskeletal Signaling|||Angiogenesis

• Bioactivity:

  BCR-ABL-IN-9 (Compound B1) is an inhibitor of BCR-ABL that achieves sustained suppression through the formation of stable covalent bonds with the ABL kinase. It effectively inhibits the activity of ABL kinase (IC50 = 1.2 nM) and possesses anticancer activity.

• Smiles:

  O=C(NC1=CC=CC(=C1)C(=O)C)C2=CC=3C=C4C5=C(C3OC2=N)CCCN5CCC4

• Molecular Formula:

  C22H20N4O3

• Molecular Weight:

  388.42

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C