GDCNF-11

CAT: 0931-T200693-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T200693-01Size:10 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2991588-80-6

Target

PROTACs, Ferroptosis, Glutathione Peroxidase

Related Pathways

Apoptosis, Metabolism, PROTAC

Bioactivity

GDCNF-11, an HSP90-based HIM-PROTACGPX4 degrader, facilitates the ubiquitination and degradation of GPX4 through the HSP90 chaperone complex. This reduction in endogenous GPX4 induces ferroptosis in HT-1080 cells, with a DC50 value of 0.08 μM.

Smiles

O=C(NCCC=1C=CC=CC1)C(C=2SC=CC2)N(C(=O)CCl)C3=CC=C(OCC=4N=NN(C4)CC(=O)N5CCC(CCNC6=NC(=NC7=C6N=CN7CC8=NC=C(C(OC)=C8C)C)N)CC5)C(Cl)=C3

Molecular Formula

C48H53Cl2N13O5S

Molecular Weight

994.99

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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GDCNF-11

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