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XMD15-44

CAT: 0931-T200297-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T200297-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1240489-67-1
Target
C-RET
Related Pathways
Tyrosine Kinase/Adaptors, Apoptosis
Bioactivity
XMD15-44, a RET kinase inhibitor, demonstrates potent growth-inhibitory effects on RAT1 cells transformed by RET/C634R and RET/M918T, with IC50 values of 11.5 nM and 8.3 nM, respectively. It effectively inhibits RET kinase activity and signaling in human thyroid cancer cell lines harboring oncogenic RET alleles, thereby reducing cell proliferation.
Smiles
O=C(NC1=CC=C(C(=C1)C(F)(F)F)CN2CCN(CC)CC2)C3=CC=C(C(C#CC=4C=NC=CC4)=C3)C
Molecular Formula
C29H29F3N4O
Molecular Weight
506.56
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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