Products for Research Use Only

NMS-P626

CAT: 0013-GTR19239215-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19239215-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NMS-P626 is a potent pan-TRK inhibitor with IC50 values of 8, 7, and 3 nM for TRKA, TRKB, and TRKC, respectively. It demonstrates anti-proliferative activity in KM12 colorectal cancer cells (IC50=19 nM) by blocking TPM3-TRKA phosphorylation and downstream signaling, making it a useful tool for oncology research.
CAS Number
942471-37-6
Field of Research
Neuroscience, Signal Transduction
Smiles
N (C (=O) C1=C (N[C@@H] (COC) C) C=C (C=C1) N2CCN (C) CC2) C=3C4=C (NN3) CCN (S (=O) (=O) C5=CC (F) =CC (F) =C5) C4
Molecular Formula
C28H35F2N7O4S
Molecular Weight
603.68
Storage Conditions
-20°C
Notes
For research use only.