INOS/TopoI-IN-1

CAT: 0931-T200135-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T200135-01Size:10 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Target

NF-κB, Apoptosis, Topoisomerase, NO Synthase

Related Pathways

Apoptosis, DNA Damage/DNA Repair, Immunology/Inflammation, NF-κB

Bioactivity

Compound AuL9, also known as iNOS/TopoI-IN-1, is a multi-target hybrid molecule possessing anti-tumor, anti-inflammatory, and antioxidant properties. This compound effectively inhibits the growth of MCF-7 and MDA MB-231 breast cancer cells in vitro, exhibiting IC50 values of 3.5 μM and 6.3 μM respectively. It also prompts DNA damage and apoptosis in these cells by inhibiting human topoisomerase I (TopoI) with a K_i of 2.72 μM. Additionally, iNOS/TopoI-IN-1 reduces the expression of iNOS by suppressing the activation of NF-kB, with a K_i of 1.49 μM.

Molecular Formula

C34H40AuBrCl2N3OS

Molecular Weight

886.54

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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Alternative Products

Catalog	Name
HY-162805	INOS/TopoI-IN-1
HY-158138	TOPOI/PARP-1-IN-1
HY-169299	TOPOI/PARP-1-IN-2
GTR19185582-01	INOs-IN-1
HY-146167	INOS/PGE2-IN-1
524425-01	INOS
HY-161513	INOS/COX-2-IN-1
PPL50133-2a	PcDNA3.1-iNOS-Myc
M37327-01	INOS-IN-14
70R-50136	iNOS antibody

INOS/TopoI-IN-1

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