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PROTAC FGFR2 degrader 1

CAT: 0931-T200117-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T200117-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Target
Apoptosis, PROTACs, FGFR
Related Pathways
PROTAC, Tyrosine Kinase/Adaptors, Apoptosis, Angiogenesis
Bioactivity
PROTAC FGFR2 degrader 1 (compound N5) is a potent PROTAC that efficiently targets FGFR2, boasting a DC 50 value of 6.46 nM and an FGFR2 IC 50 of 0.08 nM. This compound exhibits significant anti-proliferative effects and high selectivity. It induces G0/G1 arrest in the cell cycles of KATOIII and SNU16 and inhibits apoptosis by diminishing the activation of p-ERK and p-PLCγ, the downstream proteins of FGFR2. Additionally, PROTAC FGFR2 degrader 1 maintains over 50% inhibition of gastric cancer cells at a concentration of 0.17 nM and effectively suppresses the growth of SNU16 xenograft tumors in a mouse model.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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