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IDO1 Polyclonal Antibody

CAT: 0763-D-AB-10451L-01Size: 25 µLDry Ice: NoHazardous: No
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CAT#:0763-D-AB-10451L-01Size:25 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Indoleamine 2,3-dioxygenase (IDO) is a heme enzyme that initiates the oxidative degradation of the least abundant, essential amino acid, l-tryptophan, along the kynurenine pathway. This protein is normally expressed in the dendritic cells, macrophages, microglia, eosinophils, fibroblasts, endothelial cells, and most tumor cells. IDO activity is associated with immunosuppression and immune attenuation. Several studies showed that IDO can contribute to immune escape when expressed directly in tumor cells or when expressed in immunosuppressive antigen presenting cells such as tolerogenic dendritic cells or tumor associated macrophages. IDO also is a promising therapeutic target for the treatment of cancer, chronic viral infections, and other diseases characterized by pathological immune suppression.
Abbreviation
IDO1
UniProt
P14902
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant Human IDO1 protein expressed by E.coli
Target
Indole 2;3-dioxygenase; Indoleamine 2;3-dioxygenase 1; IDO-1; IDO1; IDO; INDO
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
IHC
Field of Research
Cardiovascular; Metabolism; Signal Transduction
Purification
Antigen Affinity Purification
Concentration
1 mg/mL
Dilution
IHC 1:150-1:300
Buffer
PBS with 0.02% sodium azide,1% protective protein and 50% glycerol, pH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Isotype
IgG

UniProtKB · P14902

Indoleamine 2,3-dioxygenase 1

I23O1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P14902
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
IDO1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
IDO-1
EC number
1.13.11.52
Processing
—
Secondary accessions
E5RGR8, F6M9T7, Q540B4
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Cellular component

Cytoplasm

Molecular function

DioxygenaseOxidoreductase

Ligand

HemeIronMetal-binding

Biological process

ImmunityTryptophan catabolism

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