Products for Research Use Only
RegisterLogin

Recombinant human CTLA4 protein

CAT: 0112-ATGP3914-250Size: 250 µgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0112-ATGP3914-250Size:250 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
CTLA-4, also known as cytotoxic T-lymphocyte protein 4, is a type I transmembrane T cell inhibitory molecule that is a member of the Ig superfamily. The affinity of CTLA-4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. Recombinant human CTLA-4, fused to hIgG His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Specifications
Human CTLA-4 inhibits Human B7 1/CD80 induced IL-2 secretion of the Jurkat human acute T cell leukemia cells. The ED50 range ≤150 ng/mL.
Product Name Alternative
Cytotoxic T-lymphocyte protein 4 isoform CTLA4-TM precursor, Cytotoxic T-lymphocyte-associated antigen 4, CTLA-4, CD152, CELIAC3, Celiac disease 3, Insulin-dependent diabetes mellitus 12, IDDM12, CD, GSE
Expression System
Baculovirus
Antigen Species
Human
Tag
HIgG-His-Tag
Applications
SDS-PAGE, Bioactivity
Concentration
0.5 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 95% by SDS-PAGE
Bioactivity
The activity is determined by the IL-2 ELISA in a using Jurkat human acute T cell leukemia cells. The ED50 range ≤150 ng/mL with Human B7 1/CD80.
Molecular Weight
40.8 kDa (368aa)
Additionnal Information
Cytotoxic T lymphocyte protein 4 isoform CTLA4-TM precursor, Cytotoxic T-lymphocyte-associated antigen 4, CTLA 4, CTLA4, CTLA-4, CD 152, CD152, CELIAC3, CELIAC 3, Celiac disease 3, Insulin-dependent diabetes mellitus 12, Insulin dependent diabetes mellitus 12, IDDM 12, IDDM12, CD, GSE, ATGP3914-10 µg, ATGP3914-20 µg, ATGP3914-50 µg, ATGP3914-100 µg, ATGP3914-250 µg, ATGP3914-500 µg, ATGP3914-1 mg, ATGP3914-010, ATGP3914-020, ATGP3914-050, ATGP3914-100, ATGP3914-250, ATGP3914-500, ATGP3914-01M, ATGP3364
References & Citations
Harper K., et al. (1991) J. Immunol. 147:1037-1044.; ; Teft WA., et al. (2006) Annu. Rev. Immunol. 24:65-97.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Immunology
NCBI Accession Number
NP_005205
Uniprot Accession Number
P16410
Species
Human
N Terminal Sequence
Ala
AA Sequence
KAMHVAQ PAVVLASSRG IASFVCEYAS PGKATEVRVT VLRQADSQVT EVCAATYMMG NELTFLDDSI CTGTSSGNQV NLTIQGLRAM DTGLYICKVE LMYPPPYYLG IGNGTQIYVI DPEPCPDSD

Related Products

CatalogName
ATGP4046-020Recombinant mouse CTLA4 protein
ATGP4046-250Recombinant mouse CTLA4 protein
ATGP4046-010Recombinant mouse CTLA4 protein
ATGP4046-100Recombinant mouse CTLA4 protein
ATGP4046-050Recombinant mouse CTLA4 protein
ATGP4046-500Recombinant mouse CTLA4 protein
ATGA0572-050Human CTLA4 antibody
ATGA0572-100Human CTLA4 antibody
ATGP3918-050Recombinant human CTLA-4 protein
ATGP3918-020Recombinant human CTLA-4 protein

Alternative Products

CatalogName
TP727566CTLA4 Human Recombinant Protein
CRP1383-01Recombinant Human CTLA4 Protein
PROTP16410-3-500ugHuman recombinant CTLA4 protein
RP053469CTLA4 Recombinant Protein (Human)
OPCD02505-200UGCTLA4 Recombinant Protein
MBS7609490-01Recombinant Human CTLA4

Popular Products