Products for Research Use Only
RegisterLogin

Recombinant mouse CTLA4 protein

CAT: 0112-ATGP4046-010Size: 10 µgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0112-ATGP4046-010Size:10 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Ctla-4, also known as cytotoxic T-lymphocyte protein 4 isoform 1, is a type 1 membrane protein and a memberof the immunoglobulin-superfamily. Besides, this protein contains an extra cellular domain, a transmembranedomain and a cytoplasmic tail. It is generally expressed with highest levels in lymphoid tissues. Also, it is similarto T-cell costimulatory protein CD28 since both of the molecules bind to CD80 and CD86 on antigen-presenting cells. CTLA4 and CD28 effectively regulate to T cell responses as opposing signals transmitted through tworelated cell-surface receptors. Recombinant mouse Ctla-4, fused to hIgG-His-tag at C-terminus, was expressed ininsect cell and purified by using conventional chromatography techniques.
Specifications
Mouse Ctla4 inhibits IL-2 secretion of the stimulated Jurkat human acute T cell leukemia cells with Human B7-1/CD80. The ED50 range ≤150 ng/mL.
Product Name Alternative
Ly-56, Ly-5, Cytotoxic T-lymphocyte-associated antigen 4, Cytotoxic T-lymphocyte protein 4 isoform 1, Ctla-4, CTLA4, CTLA, Cd152
Expression System
Baculovirus
Antigen Species
Mouse
Tag
HIgG-His-Tag
Applications
SDS-PAGE, Bioactivity
Concentration
0.5 mg/mL (determined by Absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS - PAGE
Bioactivity
The activity is determined by the IL-2 ELISA in a using stimulated Jurkat human acute T cell leukemia cells with Human B7-1/CD80. The ED50 range ≤150 ng/mL.
Molecular Weight
40.6kDa (363aa)
Additionnal Information
ATGP4046-10 µg, ATGP4046-20 µg, ATGP4046-50 µg, ATGP4046-100 µg, ATGP4046-250 µg, ATGP4046-500 µg, ATGP4046-1 mg, ATGP4046-10, ATGP4046-20, ATGP4046-50, ATGP4046-100, ATGP4046-250, ATGP4046-500, ATGP4046-1, ATGP3321
References & Citations
Krummey SM., et al. (2014) J. Immunol. 192:2495-2504.; ; Jain N., et al. (2013) Nat. Med. 19:1632-1637.; ; Yu CR., et al. (2013) J. Immunol. 191:5036-5043.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Immunology
NCBI Accession Number
NP_033973.2
Uniprot Accession Number
P09793
Species
Mouse
N Terminal Sequence
Ile 38

Related Products

CatalogName
ATGP1959-100Recombinant human CTLA4 protein
ATGP3914-100Recombinant human CTLA4 protein
ATGP3914-050Recombinant human CTLA4 protein
ATGP3914-020Recombinant human CTLA4 protein
ATGP3914-010Recombinant human CTLA4 protein
ATGP3914-250Recombinant human CTLA4 protein
ATGP3914-500Recombinant human CTLA4 protein
ATGP1959-500Recombinant human CTLA4 protein
ATGP1959-020Recombinant human CTLA4 protein
ATGA0572-050Human CTLA4 antibody

Alternative Products

CatalogName
PROTP09793-1-500ugMouse recombinant CTLA4 protein
TP727662Ctla4 Mouse Recombinant Protein
ARP1769-01Recombinant Mouse Ctla4 Protein
OPCA05243-1MGCTLA4 Recombinant Protein (Mouse)
TP723873Ctla4 (NM_009843) Mouse Recombinant Protein
OPCD02503-200UGCTLA4 Recombinant Protein
PPT-16337Mouse CD152/CTLA4 Recombinant Protein
GTR18905753-01Mouse CTLA4 protein

Popular Products