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Human CTLA4 antibody

CAT: 0112-ATGA0572-050Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0112-ATGA0572-050Size:50 µL
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Description
CTLA4 (Cytotoxic T-Lymphocyte Antigen 4), also known as CD152, is a protein receptor that downregulates the immune system. CTLA4 is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Mutations in CTLA4 have been associated with insulin-dependent diabetes mellitus, Graves' disease, Hashimoto's thyroiditis, celiac disease and other autoimmune diseases.
Product Name Alternative
Cytotoxic T-lymphocyte protein 4 isoform CTLA4-TM precursor, Cytotoxic T-lymphocyte-associated antigen 4, CTLA-4, CD152, CELIAC3, Celiac disease 3, Insulin-dependent diabetes mellitus 12, IDDM12, CD, GSE
Host
Mouse
Antigen Species
Human
Reactivity
Human
Immunogen
Recombinant human CTLA4 (36-161aa) purified from E. coli
Clonality
Monoclonal
Isotype
IgG1 κ
Clone
AT4C8
Conjugation
Unconjugated
Applications
ELISA, WB
Purification Method
By protein-G affinity chromatography
Concentration
1 mg/mL (determined by BCA assay)
Additionnal Information
CTLA4, ATGA0572-10 µg, ATGA0572-20 µg, ATGA0572-50 µg, ATGA0572-100 µg, ATGA0572-250 µg, ATGA0572-500 µg, ATGA0572-1 mg, ATGA0572-10, ATGA0572-20, ATGA0572-50, ATGA0572-100, ATGA0572-250, ATGA0572-500, ATGA0572-1
References & Citations
Dariavach. P., et al. (1988) Eur J Immunol 18 (12) : 1901-1905.; ; Waterhouse. P., et al. (1995) Science 270 (5238) : 985-988.; ; Magistrelli. G., et al. (1999) Eur J Immunol 29 (11) : 3596-3602.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol
Applications Notes
The antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.
Scientific Category
Stem cell
NCBI Accession Number
NP_005205
Uniprot Accession Number
P16410
WB Description
The tissue and cell lysates (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human CTLA4 antibody (1:500) . Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Lane 1.: Mouse liver tissue lysate; ; Lane 2.: TF-1 cell lysate; ; Lane 3.: HepG2 cell lysate; ; Lane 4.: WiDr cell lysate;

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