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Human LRPAP antibody

CAT: 0112-ATGA0321-100Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0112-ATGA0321-100Size:100 µL
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Description
Alpha-2-macroglobulin receptor-associated protein, also known as low density lipoprotein receptor-related protein-associated protein 1, RAP and LRPAP1, is a 39 kDa protein and a member of the alpha-2-MRAP family. LRPAP1 is a receptor antagonist that interacts with several members of the low density lipoprotein (LDL) receptor gene family. Upon binding to these receptors, LRPAP1 inhibits all ligand interactions with the receptors. LRPAP1 is present on cell surface forming a complex with the alpha-2-macroglobulin receptor heavy and light chains. LRPAP1 is present on the cell surface, where it is an effective inhibitor of ligand binding to the kidney glycoprotein 330 (gp330) yet it is most abundant in the endoplasmic reticulum lumen and may function in receptor folding and/or trafficking.
Product Name Alternative
Alpha-2-macroglobulin receptor-associated protein, A2MRAP, A2RAP, HBP44, MGC138272, MRAP, RAP
Host
Mouse
Antigen Species
Human
Reactivity
Human
Immunogen
Recombinant human LRPAP1 (35-357aa) purified from E. coli
Clonality
Monoclonal
Isotype
IgG1 κ
Clone
AT8G8
Conjugation
Unconjugated
Applications
ELISA, WB, ICC/IF
Purification Method
By protein-A affinity chromatography
Concentration
1 mg/mL (determined by BCA assay)
Additionnal Information
LRPAP, ATGA0321-10 µg, ATGA0321-20 µg, ATGA0321-50 µg, ATGA0321-100 µg, ATGA0321-250 µg, ATGA0321-500 µg, ATGA0321-1 mg, ATGA0321-10, ATGA0321-20, ATGA0321-50, ATGA0321-100, ATGA0321-250, ATGA0321-500, ATGA0321-1
References & Citations
Kounnas. M.Z., et al. (1992) J Biol Chem 267 (29) :21162-21166.; ; Bu. G., et al. (1995) EMBO J 14 (10) :2269-2280.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol
Applications Notes
The antibody has been tested by ELISA, Western blot and ICC/IF analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.
Scientific Category
Metabolism
NCBI Accession Number
NP_002328
Uniprot Accession Number
P30533
WB Description
The tissue lysate (40ug) was resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human LRPAP antibody (1:500) . Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.; ; Lane 1.: Mouse kidney tissue lysate
IF Description
ICC/IF analysis of LRPAP in HeLa cells. The cell was stained with ATGA0321 (1:100) . The secondary antibody (green) was used Alexa Fluor 488. DAPI was stained the cell nucleus (blue) .

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