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Human GARS antibody

CAT: 0112-ATGA0318-050Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0112-ATGA0318-050Size:50 µL
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Description
GARS, also known as glycyl-tRNA synthetase, is one of the aminoacyl-tRNA synthetase that charge tRNAs with their cognate amino acids. Defects in the gene encoding GlyRS is the cause of Charcot-Marie-Tooth disease type 2D (CMT2D), which is an autosomal dominant inherited disease characterized by severe weakness, atrophy and absence of deep tendon reflexes in the upper extremities. Defects in the GlyRS gene is also the cause of distal hereditary muscular neuropathy type V (HMN5), a disease similar to CMT2D, though the distal sensory involvement is less severe in HMN5 patients.
Product Name Alternative
Glycyl-tRNA synthetase, CMT2D, DSMAV, GlyRS, HMN5, SMAD1
Host
Mouse
Antigen Species
Human
Reactivity
Human
Immunogen
Recombinant human GARS (43-289aa) purified from E. coli
Clonality
Monoclonal
Isotype
IgG1 κ
Clone
AT4E10
Conjugation
Unconjugated
Applications
ELISA, WB, ICC/IF
Purification Method
By protein-A affinity chromatography
Concentration
1 mg/mL (determined by BCA assay)
Additionnal Information
GARS, ATGA0318-10 µg, ATGA0318-20 µg, ATGA0318-50 µg, ATGA0318-100 µg, ATGA0318-250 µg, ATGA0318-500 µg, ATGA0318-1 mg, ATGA0318-10, ATGA0318-20, ATGA0318-50, ATGA0318-100, ATGA0318-250, ATGA0318-500, ATGA0318-1
References & Citations
Xie. W. (2007) Proc Natl Acad Sci U S A. 104: 9976-9981.; ; Antonellis. A. (2003) AM J Hum Genet 72: 1293-1299.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol
Applications Notes
The antibody has been tested by ELISA, Western blot and ICC/IF analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.
Scientific Category
Epigenomics (Transcription & Translation)
NCBI Accession Number
NP_002038
Uniprot Accession Number
P41250
WB Description
The cell lysates (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human GARS (1:1000) . Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.; ; Lane 1.: HeLa cell lysate; ; Lane 2.: 293T cell lysate; ; Lane 3.: Jurkat cell lysate; ; Lane 4.: U87-MG cell lysate; ; Lane 5.: A431 cell lysate;
IF Description
ICC/IF analysis of GARS in HeLa cells. The cell was stained with ATGA0318 (1:100) . The secondary antibody (green) was used Alexa Fluor 488. DAPI was stained the cell nucleus (blue) .

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