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Human alpha-Synuclein antibody

CAT: 0112-ATGA0244-050Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0112-ATGA0244-050Size:50 µL
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Description
Alpha-synuclein (amino acids 1-140), an acidic neuronal protein of 140 amino acids, is extremely heat-resistant and is natively unfolded with an extended structure primarily composed of random coils. alpha-synuclein has been suggested to be implicated in the pathogenesis of Parkinson's disease and related neurodegenerative disorders, and more recently, to be an important regulatory component of vesicular transport in neuronal cells.
Product Name Alternative
SNCA, NACP, PARK1, PARK4, PD1, α-synuclein Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, Parkinson disease 4, autosomal dominant Lewy body
Host
Mouse
Antigen Species
Human
Reactivity
Human
Immunogen
Recombinant human alpha-synuclein (1-140aa) purified from E. coli
Clonality
Monoclonal
Isotype
IgG1 κ
Clone
AT1E10
Conjugation
Unconjugated
Applications
ELISA, WB, ICC/IF
Purification Method
By protein-A affinity chromatography
Concentration
1 mg/mL (determined by BCA assay)
Additionnal Information
A-Synuclein, ATGA0244-10 µg, ATGA0244-20 µg, ATGA0244-50 µg, ATGA0244-100 µg, ATGA0244-250 µg, ATGA0244-500 µg, ATGA0244-1 mg, ATGA0244-10, ATGA0244-20, ATGA0244-50, ATGA0244-100, ATGA0244-250, ATGA0244-500, ATGA0244-1
References & Citations
Jakes, R., et al. (1994) FEBS lett. 345:27-32. ; ; Ueda, K., et al. (1993) Proc. Natl.Acad. Sci. USA 90:11282-11286. ; ; Kim, J. (1997) Molecules and Cells 7:78-83.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol
Applications Notes
The antibody has been tested by ELISA, Western blot and ICC/IF analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.
Scientific Category
Neuroscience
NCBI Accession Number
NP_000336
Uniprot Accession Number
P37840
WB Description
The recombinant human synuclein family (alpha-, beta- and gamma-) proteins (100ng) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human alpha-synuclein antibody (1:500) . Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.; ; Lane 1.: alpha-synuclein ; ; Lane 2.: beta-synuclein ; ; Lane 3.: gamma-synuclein
IF Description
ICC/IF analysis of alpha-synuclein in LnCap cells. The cell was stained with ATGA0244 (1:100) . The secondary antibody (green) was used Alexa Fluor 488. DAPI was stained the cell nucleus (blue) .ICC/IF analysis of alpha-synuclein in HeLa cells. The cell was stained with ATGA0244 (1:100) . The secondary antibody (green) was used Alexa Fluor 488. DAPI was stained the cell nucleus (blue) .{ATGA0244-IF2.jpg}

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