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Recombinant human alpha-Synuclein (A30P) protein

CAT: 0112-SNA2003-500Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0112-SNA2003-500Size:500 µg
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Description
A Parkinson's disease-related point mutant (A30P) of alpha-synuclein. A30P mutant of alpha-synuclein was overexpressed in E. coli and the recombinant protein was purified to apparent homogeneity by taking advantage of the thermosolubility of the protein and by using conventional column chromatography techniques.
Product Name Alternative
SNCA, NACP, PARK1, PARK4, PD1, α-synuclein Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, Parkinson disease 4, autosomal dominant Lewy body
Expression System
E.coli
Antigen Species
Human
Tag
Non-Tagged
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by BCA assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
14.4 kDa (140aa) confirmed by MALDI-TOF
Additionnal Information
A-Synuclein (A30P), SNCA, NACP, PARK1, alpha-Synuclein, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, Alpha synuclein, Alpha-synuclein isoform NACP140, alphaSYN, MGC105443, MGC110988, MGC127560, MGC64356, Non A beta component of AD amyloid, Non A4 component of amyloid precursor, Non-A-beta component of alzheimers disease amyloid, precursor of PARK 1, PARK 4, PARK4, Parkinson disease familial 1, PD 1, PD1, Synuclein alpha, SNA2003-10 µg, SNA2003-20 µg, SNA2003-50 µg, SNA2003-100 µg, SNA2003-250 µg, SNA2003-500 µg, SNA2003-1 mg, SNA2003-10, SNA2003-20, SNA2003-50, SNA2003-100, SNA2003-250, SNA2003-500, SNA2003-1
References & Citations
Kruger R., et al. (1998) Nat Genet. 18, 106-108.; ; Park, SM. et al. (2002) Blood. 100 (7),2506-2514;
Other References
Park JY, et al. Microglial phagocytosis is enhanced by monomeric alpha-synuclein, not aggregated alpha-synuclein: implications for Parkinsons disease. (Glia. 2008) {https://pubmed.ncbi.nlm.nih.gov/18449945/}; ; Kim KS, et al. Proteolytic cleavage of extracellular α-synuclein by plasmin: implications for Parkinson disease. (J Biol Chem. 2012) {https://pubmed.ncbi.nlm.nih.gov/22619171/}; ; Konno M, et al. Suppression of dynamin GTPase decreases α-synuclein uptake by neuronal and oligodendroglial cells: a potent therapeutic target for synucleinopathy. (Mol Neurodegener. 2012) {https://pubmed.ncbi.nlm.nih.gov/22892036/}
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 7.5) containing 0.1M NaCl,10% glycerol
Scientific Category
Neuroscience
NCBI Accession Number
NP_000336.1
Uniprot Accession Number
P37840
Species
Human
AA Sequence
MDVFMKGLSK AKEGVVAAAE KTKQGVAEAP GKTKEGVLYV GSKTKEGVVH GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA

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