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Human EPM2A antibody

CAT: 0112-AEP0911-050Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0112-AEP0911-050Size:50 µL
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Description
Epilepsy, progressive myoclonus type 2A (EPM2A), also known as laforin, is a dual-specificity phosphatase that associates with polyribosomes. The protein may be involved in the control of glycogen metabolism, particularly in monitoring for and preventing the formation of poorly branched glycogen molecules. Defects in EPM2A are a cause of progressive myoclonic epilepsy type 2 (EPM2), also known as Lafora disease. EPM2 is an autosomal recessive and severe form of adolescent-onset progressive epilepsy.
Product Name Alternative
Laforin isoform a, epilepsy, progressive myoclonus type 2A Lafora disease (laforin), epilepsy progressive myoclonus type 2 Lafora disease (laforin), LDE, LD
Host
Mouse
Antigen Species
Human
Reactivity
Human
Immunogen
Recombinant human EPM2A (243-331aa) purified from E. coli
Clonality
Monoclonal
Isotype
IgG1 κ
Clone
K2A3
Conjugation
Unconjugated
Applications
ELISA, WB, ICC/IF
Purification Method
By protein-G affinity chromatography
Concentration
1 mg/mL (determined by BCA assay)
Additionnal Information
EPM2A, AEP0911-10 µg, AEP0911-20 µg, AEP0911-50 µg, AEP0911-100 µg, AEP0911-250 µg, AEP0911-500 µg, AEP0911-1 mg, AEP0911-10, AEP0911-20, AEP0911-50, AEP0911-100, AEP0911-250, AEP0911-500, AEP0911-1
References & Citations
Tagliabracci V.S., et al. (2007) Proc Natl Acad Sci U S A. 104 (49) :19262-19266.; ; Wang W., et al. (2006) Biochem Biophys Res Cimmun. 350 (3) :588-592.; ; Ganesh S., et al. (2002) Hum Mol Genet. 11:1263-1271.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol
Applications Notes
The antibody has been tested by ELISA, Western blot and ICC/IF analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.
Scientific Category
Enzymes & Proteases
NCBI Accession Number
NP_005661
Uniprot Accession Number
O95278
WB Description
The cell lysates of HeLa and 293T (20 µg) were resolved by SDS-PAGE, transferred to NC membrane and probed with anti-human EPM2A (1:1000) . Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.
IF Description
ICC/IF analysis of EPM2A in HeLa cells. The cell was stained with AEP0911 (1:100) . The secondary antibody (green) was used Alexa Fluor 488. DAPI was stained the cell nucleus (blue) .

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PT_74230-01Laforin, Mouse Anti Human (EPM2A Antibody)
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