Propargyl-PEG8-NHS ester

CAT: 0804-HY-130376-01Size: 100 mgDry Ice: NoHazardous: No
CAT#:0804-HY-130376-01Size:100 mg
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Description
Propargyl-PEG8-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG8-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. Propargyl-PEG8-NHS ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
CAS Number
[2182601-74-5]
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
ADC Linker; PROTAC Linkers
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/propargyl-peg7-c2-nhs-ester.html
Purity
97.0
Solubility
10 mM in DMSO
Smiles
C#CCOCCOCCOCCOCCOCCOCCOCCOCCC(ON1C(CCC1=O)=O)=O
Molecular Formula
C24H39NO12
Molecular Weight
533.57
Precautions
H302, H315, H319, H335
References & Citations
[1]Satwik Kamtekar, et al. Modified biotin-binding proteins for immobilization. WO2019126734A1.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Alkyl/ether Linkers; Cleavable Linker; PEG Linkers

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