Propargyl-PEG2-NHS ester

• Description :

  Propargyl-PEG2-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG2-NHS ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319, H335

• Target :

  PROTAC Linkers

• Type :

  Reference compound

• Related Pathways :

  PROTAC

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/propargyl-peg2-nhs-ester.html

• Purity :

  98.0

• Solubility :

  DMSO : 250 mg/mL (ultrasonic)

• Smiles :

  O=C(CCOCCOCC#C)ON1C(CCC1=O)=O

• Molecular Formula :

  C12H15NO6

• Molecular Weight :

  269.25

• Precautions :

  H315, H319, H335

• References & Citations :

  [1]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27 (8) :998-1014.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  PEG Linkers

• CAS Number :

  [2512228-06-5]