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IL1AP rabbit pAb

CAT: 0855-ES15483-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES15483-01Size:50 µL
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Background
Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This gene encodes the interleukin 1 receptor accessory protein. The protein is a necessary part of the interleukin 1 receptor complex which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress. [provided by RefSeq, Nov 2009]
Description
Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This gene encodes the interleukin 1 receptor accessory protein. The protein is a necessary part of the interleukin 1 receptor complex which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress. [provided by RefSeq, Nov 2009],
Product Name Alternative
Interleukin-1 receptor accessory protein (IL-1 receptor accessory protein) (IL-1RAcP) (Interleukin-1 receptor 3) (IL-1R-3) (IL-1R3)
UniProt
Q9NPH3
Swiss Prot
Q9NPH3
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from human IL1AP AA range: 213-263
Target
IL1AP
Clonality
Polyclonal
Source
Rabbit
Applications
WB
Concentration
1 mg/ml
Dilution
WB 1:500-2000
Buffer
-20°C/1 year
Molecular Weight
65kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
65kD
Fragment
IgG
Subcellular Location
[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.; [Isoform 3]: Secreted.
Other Product Names
Interleukin-1 receptor accessory protein (IL-1 receptor accessory protein) (IL-1RAcP) (Interleukin-1 receptor 3) (IL-1R-3) (IL-1R3)
Gene ID (Human)
3556

UniProtKB · Q9NPH3

Interleukin-1 receptor accessory protein

IL1AP_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9NPH3
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
IL1RAP
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
IL-1 receptor accessory protein, IL-1RAcP
EC number
3.2.2.6
Processing
Precursor
Secondary accessions
B1NLD0, D3DNW0, O14915, Q86WJ7
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneMembraneSecreted

PTM

Disulfide bondGlycoproteinPhosphoprotein

Molecular function

HydrolaseReceptor

Biological process

ImmunityInflammatory responseInnate immunity

Domain

Immunoglobulin domainRepeatSignalTransmembraneTransmembrane helix

Ligand

NAD

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