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PAF-R Antibody

CAT: 1071-OM635598-01Size: 100 µLDry Ice: NoHazardous: No
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CAT#:1071-OM635598-01Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants.
Immunogen
The antiserum was produced against synthesized peptide derived from human PTAFR. AA range:194-243
Antibody Type
Primary Antibodies
Product Name Synonym
PTAFR antibody; PAFR antibody; Platelet-activating factor receptor antibody; PAF-R antibody; PAFr antibody

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