PTC-209 (hydrobromide)

• Description :

  PTC-209 hydrobromide is a specific BMI-1 inhibitor with an IC50 of 0.5 μM in HEK293T cell line. PTC-209 hydrobromide irreversibly impairs colorectal cancer-initiating cells (CICs) . PTC-209 hydrobromide shows potent anti-myeloma activity and impairs the tumor microenvironment[1][2].

• UNSPSC :

  12352005

• Target :

  Autophagy; BMI1

• Type :

  Reference compound

• Related Pathways :

  Autophagy; Stem Cell/Wnt

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/PTC-209-hydrobromide.html

• Purity :

  99.02

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  CC1=C(C2=CSC(NC3=C(Br)C=C(OC)C=C3Br)=N2)N4C=CC=NC4=N1.Br

• Molecular Formula :

  C17H14Br3N5OS

• Molecular Weight :

  576.10

• References & Citations :

  [1]Kreso A, et al. Self-renewal as a therapeutic target in human colorectal cancer. Nat Med. 2014 Jan;20 (1) :29-36.|[2]Christian Mayr, et al. The BMI1 inhibitor PTC-209 is a potential compound to halt cellular growth in biliary tract cancer cells. Oncotarget. 2016 Jan 5; 7 (1) : 745-758.|[3]Shahi MH, et al. BMI1 is expressed in canine osteosarcoma and contributes to cell growth and chemotherapy resistance. PLoS One. 2015 Jun 25;10 (6) :e0131006.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1217022-63-3]