(±)-ML 209

(±)-ML 209

• CAS Number: 1334526-14-5
• UNSPSC Description: (±)-ML 209 (compound 4n), a diphenylpropanamide, is a retinoic acid-related orphan receptor RORγ antagonist with an IC50 of 1.1 μM. (±)-ML 209 inhibits RORγt transcriptional activity with an IC50 of 300 nM in HEK293t cells. (±)-ML 209 inhibits the transcriptional activity of RORγt, but not RORα in cells. (±)-ML 209 selectively inhibits murine Th17 cell differentiation without affecting the differentiation of naïve CD4+ T cells into other lineages, including Th1 and regulatory T cells[1].
• Target Antigen: ROR
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/racemic-ml-209.html
• Purity: 99.87
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O=C(N(C[C@@H]1C)C[C@H](C1)C)CC(C2=CC=C3C(OCO3)=C2)C(C(O)=CC(OC)=C4)=C4OC
• Molecular Weight: 441.52
• References & Citations: [1]Jun R Huh, et al. Identification of Potent and Selective Diphenylpropanamide RORγ Inhibitors. ACS Med Chem Lett. 2013 Jan 10;4(1):79-84.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C, 3 years (Powder)
• Clinical Information: No Development Reported