Gefapixant (citrate)

CAT: 0804-HY-101588A-01Size: 5 mgDry Ice: NoHazardous: No

1 / 1

CAT#:0804-HY-101588A-01Size:5 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

Gefapixant citrate is an orally active and potent purinergic P2X3 receptor (P2X3R) antagonist, with IC50 values of ~30 nM versus recombinant hP2X3 homotrimers and 100-250 nM at hP2X2/3 heterotrimeric receptors. Gefapixant citrate can be used for the research of chronic cough and knee osteoarthritis[1][2][3].

CAS Number

2310299-91-1

Product Name Alternative

MK-7264 (citrate) ; AF-219 (citrate)

UNSPSC

12352005

Target

P2X Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

COVID-19-anti-virus

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/gefapixant-citrate.html

Purity

99.23

Solubility

DMSO : 350 mg/mL (ultrasonic)

Smiles

O=C(CC(C(O)=O)(CC(O)=O)O)O.O=S(N)(C1=C(OC)C=C(C(C)C)C(OC2=CN=C(N)N=C2N)=C1)=O

Molecular Formula

C20H27N5O11S

Molecular Weight

545.52

References & Citations

[1]Anthony P. Ford, et al. The therapeutic promise of ATP antagonism at P2X3 receptors in respiratory and urological disorders. Front Cell Neurosci. 2013; 7: 267.|[2]Ford AP, In pursuit of P2X3 antagonists: novel therapeutics for chronic pain and afferent sensitization. Purinergic Signal. 2012 Feb;8 (Suppl 1) :3-26.|[3]Martin Nguyen A, et al. Validation of a visual analog scale for assessing cough severity in patients with chronic cough. Ther Adv Respir Dis. 2021 Jan-Dec;15:17534666211049743.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

P2X3 Receptor

Chemical Information

Gefapixant Citrate

See also: Gefapixant (has active moiety).

CAS Number	2310299-91-1
PubChem CID	145720531
IUPAC Name	5-(2,4-diaminopyrimidin-5-yl)oxy-2-methoxy-4-propan-2-ylbenzenesulfonamide;2-hydroxypropane-1,2,3-tricarboxylic acid
Molecular Formula	C20H27N5O11S
Molecular Weight	545.5
Topological Polar Surface Area	297
Hydrogen Bond Donor Count	7
Hydrogen Bond Acceptor Count	16
Rotatable Bond Count	10
Heavy Atom Count	37
Formal Charge	0
Complexity	739

SMILES

CC(C)C1=CC(=C(C=C1OC2=CN=C(N=C2N)N)S(=O)(=O)N)OC.C(C(=O)O)C(CC(=O)O)(C(=O)O)O

InChI

InChI=1S/C14H19N5O4S.C6H8O7/c1-7(2)8-4-10(22-3)12(24(17,20)21)5-9(8)23-11-6-18-14(16)19-13(11)15;7-3(8)1-6(13,5(11)12)2-4(9)10/h4-7H,1-3H3,(H2,17,20,21)(H4,15,16,18,19);13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)

InChIKey

AIJVJYUOMCRFOE-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 2310299-91-1

CID: 145720531

Formula: C20H27N5O11S

MW: 545.5

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	545.5
Hydrogen Bond Donor Count	7
Hydrogen Bond Acceptor Count	16
Rotatable Bond Count	10
Exact Mass	545.14277787
Monoisotopic Mass	545.14277787
Topological Polar Surface Area	297 Å²
Heavy Atom Count	37
Formal Charge	0
Complexity	739
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	2
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
HY-101588-01	Gefapixant
HY-101588R-01	Gefapixant (Standard)
HY-13757-01	Tamoxifen (Citrate)
HY-B0463-01	Clomiphene (citrate)
HY-12642-01	Diethylcarbamazine (citrate)
HY-B0061-01	Tandospirone (citrate)
HY-15025A-01	Sildenafil (citrate)
HY-108680	Carbazeran (citrate)
HY-127141	Cizolirtine (citrate)
HY-145566A	Envonalkib (citrate)

Alternative Products

Catalog	Name
BUP14451-01	Gefapixant citrate
BM170818-01	Gefapixant
BA6848-50	Gefapixant (Standard)
TMIH-0250-01	Gefapixant-d3

Gefapixant (citrate)

Chemical Information

Related Products

Alternative Products

Popular Products