Calbindin Antibody

• Background:

  Calbindin (aka. calbindin D28k) is a member of the calcium-binding protein superfamily that includes calmodulin and troponin C. It is predominantly expressed in certain types of neurons, particularly in dendrites and perikarya of the cerebellum and is thought to buffer entry of calcium upon stimulation of glutamate receptors (Andressen et al., 1993) . Calbindin has recently been shown to play a critical role in mitochondrial dysfunction and loss of synaptic proteins in vivo in an Alzheimer’s disease mouse model (Kook et al., 2014) .

• Synonyms:

  Avian-type antibody, CAB27 antibody, CALB 1 antibody, CALB antibody, CALB1 antibody, CALB1_HUMAN antibody, Calbindin 1 28kDa antibody, Calbindin antibody, Calbindin D28 antibody, D 28K antibody, D-28K antibody, D28K antibody, OTTHUMP00000166027 antibody, OTTHUMP00000225441 antibody, RTVL H protein antibody, Vitamin D dependent calcium binding protein antibody, Vitamin D dependent calcium binding protein avian type antibody, Vitamin D-dependent calcium-binding protein antibody

• Gene ID:

  793

• Swiss Prot:

  P05937

• Host:

  Mouse

• Cross Reactivity:

  Human, Mouse, Rat, Bovine

• Target:

  Calbindin

• Clonality:

  Monoclonal

• Isotype:

  IgG2a

• Clone:

  5A9

• Conjugation:

  Unconjugated

• Source:

  Recombinant full length human calbindin purified from E. coli.

• Applications:

  WB, IHC

• Purification:

  Purified by Protein G.

• Concentration:

  Lot Dependent

• Dilution:

  WB (1:300-5000), IHC ()

• Buffer:

  PBS + 50% glycerol and 5 mM NaN3

• Modification:

  Unmodified

• Storage Conditions:

  Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

• Specificity:

  Specific for endogenous levels of the ~28 kDa calbindin protein.

• Gene ID URL:

  793