Stat1 Antibody

CAT: 0498-bsm-70684MSize: 100 µLDry Ice: NoHazardous: No
CAT#:0498-bsm-70684MSize:100 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The stat proteins function both as cytoplasmic signal transducers and as activators of transcription. Stat1 is expressed as two variants of 84 and 91 kDa. Stat1 proteins contain SH2 and SH3 domains, and are components of the interferon-stimulated gene factor 3 (ISGF3) complex. This complex is the primary transcription activator induced by the binding of interferon to its receptors. In response to activation by various cytokines and growth factors, stat1 subunits become phosphorylated at tyrosine 701. This leads to translocation of stat1 to the nucleus, resulting in formation of an active ISGF3 complex. Active ISGF3 modulates the transcription of the interferon-stimulated genes. Thus, phosphorylation of Tyr-701 is critical for gene expression mediated by various cytokines and growth factors.
Synonyms
Stat1a, Stat1b, ISGF3, Stat1alpha, Stat1beta
Swiss Prot
P42224
Host
Mouse
Cross Reactivity
Human, Mouse, Rat
Target
Stat1
Clonality
Monoclonal
Isotype
IgG1
Clone
M249
Conjugation
Unconjugated
Source
Clone (M249) was generated from a recombinant protein from human Stat1. This sequence has high homology to the conserved region in rat and mouse stat1 a and b.
Applications
WB, IP
Purification
Purified by Protein A.
Dilution
WB (1:300-5000), IP (1-2ug)
Buffer
PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol
Modification
Unmodified
Storage Conditions
Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
Specificity
The antibody detects 84 and 91 kDa* stat1 variants on SDS-PAGE immunoblots of human Jurkat and A431 cells.

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