ROS-generating agent 1

• Description :

  ROS-generating agent 1 (Compound 2c) covalently modifies the Sec-498 residue of TrxR to generate ROS. ROS-generating agent 1 reduces intracellular TrxR protein level. ROS-generating agent 1 results in ROS-dependent apoptosis and ferroptosis of NCI-H460 cells. ROS-generating agent 1 has anti-cancer activities[1].

• CAS Number :

  [2369030-41-9]

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319

• Target :

  Apoptosis; Ferroptosis; Reactive Oxygen Species (ROS) ; TrxR

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/ros-generating-agent-1.html

• Purity :

  99.11

• Solubility :

  DMSO : 33.33 mg/mL (ultrasonic)

• Smiles :

  O=C1/C(CNC/C1=C\C2=CC(C(F)(F)F)=CC=C2)=C/C3=CC=CC(C(F)(F)F)=C3

• Molecular Formula :

  C21H15F6NO

• Molecular Weight :

  411.34

• Precautions :

  H302, H315, H319

• References & Citations :

  [1]Liu X, et al. Tumor killing by a dietary curcumin mono-carbonyl analog that works as a selective ROS generator via TrxR inhibition. Eur J Med Chem. 2023 Mar 15;250:115191.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported