ROS-generating agent 1

CAT: 0804-HY-149265-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-149265-01Size:5 mg
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Description
ROS-generating agent 1 (Compound 2c) covalently modifies the Sec-498 residue of TrxR to generate ROS. ROS-generating agent 1 reduces intracellular TrxR protein level. ROS-generating agent 1 results in ROS-dependent apoptosis and ferroptosis of NCI-H460 cells. ROS-generating agent 1 has anti-cancer activities[1].
CAS Number
[2369030-41-9]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Apoptosis; Ferroptosis; Reactive Oxygen Species (ROS) ; TrxR
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ros-generating-agent-1.html
Purity
99.11
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
O=C1/C(CNC/C1=C\C2=CC(C(F)(F)F)=CC=C2)=C/C3=CC=CC(C(F)(F)F)=C3
Molecular Formula
C21H15F6NO
Molecular Weight
411.34
Precautions
H302, H315, H319
References & Citations
[1]Liu X, et al. Tumor killing by a dietary curcumin mono-carbonyl analog that works as a selective ROS generator via TrxR inhibition. Eur J Med Chem. 2023 Mar 15;250:115191.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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