D-688

• Description :

  D-688 is an inhibitor of Tau and Aβ. D-688 can reverse Aβ1–42-induced toxicity in SH-SH5Y cells and has significant neuroprotective properties. D-688 can improve the survival rate of Drosophila melanogaster expressing the human tau protein isoform (2N4R) [1].

• UNSPSC :

  12352005

• Target :

  Amyloid-β; Tau Protein

• Type :

  Reference compound

• Related Pathways :

  Neuronal Signaling

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/d-688.html

• Smiles :

  OC1=CC=C(C=C1O)C2=CC=C(C=C2)N3CCN(CC3)CCNCC4=CC=C(C=C4)F

• Molecular Formula :

  C25H28FN3O2

• Molecular Weight :

  421.51

• References & Citations :

  [1]Armstrong, et al. "Novel Piperazine Based Compounds Target Alzheimer’s Disease Relevant Amyloid β42 and Tau Derived Peptide AcPHF6, and the Lead Molecule Increases Viability in the Flies Expressing Human Tau Protein." ACS Chemical Neuroscience (2024) .

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2276762-07-1]